Hepatoprotective Activity Of Ethanolic Stem Extract Of Homalium Letestui Against Thioacetamide-Induced Liver Injury


  • Oyepata Simeon Joseph Department of Pharmacology and Toxicology,
  • Opeyemi Tosin Joseph Department of Pharmacology,


Homalium letestui, hepatoprotective, thioacetamide


There is an immensely growing demand for research into plants that is of benefit in protecting and/or healing vital organs in the body. Homalium letestui plant is a plant of folkloric importance that is used in management of several ailments. The hepatic protective ability of ethanolicextract of the plantagainst thioacetamide induced liver injury in rats was investigated. Thirty six (36) male adult abino rats were divided into 6 groups of six rats per group. Group 1 received normal saline 10 mg/kg, group 2 received thioacetamide 200 mg/kg and group 3 were administ3.ered Silymarin 100 mg/kg. Animals in group 4, 5 and
6 received 250, 500 and 750 mg/kg respectively of ethanol stem extract of Homalium letestui plant. Administration was carried out for 8 days after which animals were sacrificed. Examination of liver function parameters and histopathological observations were used to assess hepatoprotective activity of the stem extract. There was significant (p≤ 0.05) decrease in level of liver enzymesAST, ALT and ALP, increase in endogenous level of total cholesterol, total and direct bilirubin and decreases in total protein and albumin levels when compared to control. Histopathological examination agrees with that of chempathology results suggesting the plant may have organ protective ability. The extracts result was also comparable to
that of standard drug used. The result of the study shows that the plant may possess hepatoprotective activity which supports it use in traditional medicine as an antidote.

Author Biographies

Oyepata Simeon Joseph, Department of Pharmacology and Toxicology,

Faculty of Pharmacy, Gombe University of Uyo, Uyo, Nigeria.

Opeyemi Tosin Joseph, Department of Pharmacology,

Faculty of Basic Medical Sciences, University of Port Harcort, Rivers State, Nigeria.


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How to Cite

Simeon Joseph, O. ., & Tosin Joseph, O. . (2018). Hepatoprotective Activity Of Ethanolic Stem Extract Of Homalium Letestui Against Thioacetamide-Induced Liver Injury. The Nigerian Journal of Pharmacy, 52(1). Retrieved from https://www.psnnjp.org/index.php/home/article/view/38