Development and Characterization of Ibuprofen Solid Dispersion for Solubility and Dissolution improvement using a binary carrier system consisting of D-Mannitol-Polyethylene Glycol 6000

Main Article Content

Abiodun O. Shittu
Ngaitad S. Njinga
Susanna D. Orshio

Abstract

Background: Adequate drug bioavailability is a major problem in most solid dosage formulations. Recent works reported enhanced solubility and dissolution using a carrier. This study was carried out to enhance the solubility and dissolution of ibuprofen using a binary carrier system.


Method: Solid dispersions (SD) of ibuprofen were prepared using PEG 6000 and D (-) mannitol in difffferent ratios (1:0:4, 1:1:3, 1:2:2, 1:3:1, and 1:4:0) by the fusion method.


Results: Percentage yield of SD was between 96% and 99% and content analysis revealed 100 % drug content. All batches of SD showed better solubility characteristics than Ibuprofen alone or its physical mixtures. The SD batch 3, ratio 1:2:2 with equal amount of PEG and mannitol possessed the best solubility characteristic and drug release profifile with T50% at 17 min. FTIR spectral and DSC thermograms of SDs showed no interaction between the carriers and ciproflfloxacin.


Conclusion: The SD3 formulated with 20 % ibuprofen, 40 % mannitol and 40 % PEG 6000 possessed better solubility and dissolution is therefore recommended

Article Details

How to Cite
O. Shittu, A. ., S. Njinga, . N. ., & D. Orshio, S. . (2022). Development and Characterization of Ibuprofen Solid Dispersion for Solubility and Dissolution improvement using a binary carrier system consisting of D-Mannitol-Polyethylene Glycol 6000. The Nigerian Journal of Pharmacy, 56(1), 109–118 | https://doi.org/10.51412/psnnjp.2022.12. Retrieved from https://www.psnnjp.org/index.php/home/article/view/116
Section
Articles
Author Biographies

Abiodun O. Shittu, Department of Pharmaceutics and Industrial Pharmacy,

Faculty of Pharmaceutical Sciences, University of Ilorin

Ngaitad S. Njinga, Department of Pharmaceutical and Medicinal Chemistry,

Faculty of Pharmaceutical Sciences, University of Ilorin.

Susanna D. Orshio, Department of Pharmaceutics and Industrial Pharmacy,

Faculty of Pharmaceutical Sciences, University of Ilorin.

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